The folding of single domain proteins—have we reached a consensus?
نویسندگان
چکیده
منابع مشابه
Improvement in Protein Domain Identification Is Reached by Breaking Consensus, with the Agreement of Many Profiles and Domain Co-occurrence
Traditional protein annotation methods describe known domains with probabilistic models representing consensus among homologous domain sequences. However, when relevant signals become too weak to be identified by a global consensus, attempts for annotation fail. Here we address the fundamental question of domain identification for highly divergent proteins. By using high performance computing, ...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2011
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2010.11.002